A-PVP

Information

A-PVP is chemically the ketone analog of proline. Physically, it is an odorless, colorless solid crystal form. α-PVP is also chemically called α-pyrrolidinovalerophenone, 1-Phenyl-2- (pyrrolidine-1-yl) pentane-1-one, α-Pyrrolidinopentiophenone.

Chemical Properties

Pharmacology and Effects

A-PVP is a synthetic cathinone that functions as a potent inhibitor of dopamine and norepinephrine reuptake, leading to strong stimulant effects. It produces increased alertness, euphoria, and psychomotor activation similar to other pyrrolidinophenones such as MDPV.

• Mechanism of action: Dopamine and norepinephrine reuptake inhibitor
• Receptor targets: DAT > NET (no significant serotonergic activity)
• Onset: Rapid, within minutes
• Duration: 2–4 hours (variable)
• Reported effects: Stimulation, euphoria, increased energy
• Potency: High, active at low milligram doses

Risks and Side Effects

A-PVP has been linked to severe adverse effects including agitation, paranoia, tachycardia, and hyperthermia. Toxic overdoses and fatalities have been reported, especially when used in high doses or combined with other stimulants.

• Cardiovascular: Tachycardia, hypertension, chest pain
• Neurological: Agitation, tremors, seizures
• Psychiatric: Anxiety, paranoia, hallucinations
• Thermoregulatory: Hyperthermia, dehydration
• Toxicity: Documented cases of severe intoxication and death
• Dependence potential: High, with strong craving behavior

Warning